S19-02 Unravelling the cellular and molecular basis of salamander limb and tail regeneration

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S19-02 Unravelling the cellular and molecular basis of salamander limb and tail regeneration

Regeneration is a trait observed in various metazoans to differing extents. We are interested in how some species manage to regenerate complex structures and why this ability has been lost in other species. Among vertebrates, the salamanders have the most impressive regenerative abilities that includes appendage and spinal cord regeneration as well as regeneration of a number of organs such as ...

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Skeletal muscle dedifferentiation during salamander limb regeneration.

Salamanders can regenerate entire limbs throughout their life. A critical step during limb regeneration is formation of a blastema, which gives rise to the new extremity. Salamander limb regeneration has historically been tightly linked to the term dedifferentiation, however, with refined research tools it is important to revisit the definition of dedifferentiation in the context. To what exten...

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Effects of cadmium on salamander survival and limb regeneration.

INTRODUCTION The need for sensitive aquatic toxicity tests is growing with the increasingly greater number of pollutants disposed of in waterways. We have initiated studies to determine whether the salamander, Notophthnlmus \iridescens. may be a useful animal model for bioassays on water toxicity. The salamanders used in this study are aquatic amphibians which have the ability to regenerate the...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2009

ISSN: 0925-4773

DOI: 10.1016/j.mod.2009.06.1008